Elucidating genetic variations and pathophysiology linked to schizophrenia in Japanese

Tadao Arinami (Department of Medical Genetics,Graduate School of Comprehensive Human Sciences,University of Tsukuba)

 

Recent advent of genome-wide approach and exome seqeuncing have identified some de novo mutations increasing the risk of schizophrenia,particularly of sporadic schizophrenia. Most of genetic variations contributing to familial occurrence of schizophrenia are still eluding researchers because it may be the result of a combination of many genetic variations with small effects. A linkage study in Japanese sib-pairs with schizophrenia revealed the regions linked to schizophrenia. We will apply deep genome analyses to identify mutations in the chromosome regions linked to schizophrenia and develop personal genome information linked to familial occurrence of schizophrenia.